Results showed that reynoutrin significantly improved cardiac function, suppressed the release of inflammatory factors, reduced oxidative stress, inhibited cardiomyocytes apoptosis, and attenuated myocardial fibrosis in rats with IHF. Western blotting was used to determine protein expression levels of S100 calcium-binding protein A1 (S100A1), matrix metallopeptidase 2(MMP2), MMP9, phosphorylated (p-) p65, and transforming growth factor -β1 (TGF-β1) in myocardial tissue of the left ventricle. Cardiac function, inflammatory factors releasing, oxidative stress, cardiomyocytes apoptosis, and myocardial fibrosis were evaluated. The rat heart failure model was established by permanently ligating the left anterior descending coronary artery (LAD) and administering different doses of reynoutrin.
This study investigated the effects of reynoutrin on the improvement of ischemic heart failure (IHF) and its possible mechanism in rats. 2Department of Cardiac Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.1Department of Cardiovascular Surgery, Central People’s Hospital of Zhanjiang, Zhanjiang, China.Wenkai Yang 1* †, Hanjian Tu 2 †, Kai Tang 1, Haozhong Huang 1, Shi Ou 1 and Jianguo Wu 1
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